Extended Histopathology in Immunotoxicity Testing: Interlaboratory Validation Studies

New approaches to immunotoxicity testing.

New approaches to immunotoxicity testing are reviewed and discussed. A method of activating T-cells in vivo is presented which circumvents artifacts dur to viability effects encountered with in vitro mitogen assays. The use of adoptive transfer approaches to combine the advantages of in vitro manipulation with in vivo function assays is discussed relative to natural killer cells. The need for a...

CHEMICAL TESTING: Developmental Immunotoxicity in Review

Nanotechnology, the engineering of func­ tional materials at an atomic or molecular scale, has been among the fastest growing fields of science and technology. Worldwide sales of products incorporating nanotechnolo­ gy are projected to total $2.6 trillion by 2014, according to a 2004 report from Lux Research titled Sizing Nanotechnology’s Value Chain. But with the increasing use of nano materia...

Studies on histopathology of Stilesia globipunctata infections in Iran

Use of tissue microarray for interlaboratory validation of HER2 immunocytochemical and FISH testing.

AIMS To evaluate the use of tissue microarray (TMA) technology as a validation tool for HER2 testing by both immunocytochemistry (ICC) and fluorescence in situ hybridisation (FISH) in the diagnostic setting. METHODS TMA constructs from 57 cases of breast cancer were evaluated for HER2 (by ICC and FISH) by two centres. The results were compared. RESULTS There was a high level of concordance ...

Determining Consensus Values in Interlaboratory Comparisons and Proficiency Testing

An important part of interlaboratory comparisons and proficiency testing is the determination of the reference value of the measurand and the associated uncertainty. It is desirable to have reference values with low uncertainty, but it is crucial that these values are reliable, i.e. they are correct within their stated uncertainty. In some cases it is possible to obtain reference values from la...